Turmeric supplements: New study raises concerns

Research links turmeric and black pepper supplements to liver injury in some people. Learn what this means for your health.

 

The unexpected danger of turmeric and black pepper supplements For years, we've heard about the potential health benefits of turmeric supplements, but a new study published in The American Journal of Medicine reveals a concerning link between these supplements and liver injury. Researchers from the U.S. Drug-Induced Liver Injury Network identified 10 cases of turmeric-associated liver injury between 2004 and 2022, with six cases occurring since 2017. Of these, five patients were hospitalized, and one died from acute liver failure. The study found a particular risk associated with taking turmeric and black pepper supplements together. Dr. Jay Hoofnagle, one of the study's authors, explains: "Turmeric is a spice [...] it's not absorbed. The answer, we think, is that these modern products [...] have been altered so that they are absorbed." The combination of turmeric and black pepper is popular because black pepper contains piperine, which greatly enhances the absorption of curcumin, the active compound in turmeric. However, this increased absorption could be what raises the risk of liver injury. Interestingly, what's safe for one person might not be for another. People in 7 out of the 10 cases carried a specific genetic variant (HLA-B*35:01), which may increase susceptibility to this type of liver injury. It's important to note that the risk seems to be associated with supplement use, not with turmeric used as a spice in cooking. If you're taking a turmeric supplement, especially one boosted with black pepper, it might be wise to discuss the potential risks with your doctor. While turmeric may have health benefits, this study reminds us of the importance of approaching any supplement with due caution. To learn more about this study and what it means for your health, jump to "Turmeric and black pepper supplements linked to liver injury in some people" for more on the science behind this surprising discovery. Also making headlines this week: Detailed study suggests keto diet is good for the brain Drinking coffee cuts risks of sedentary lifestyle Microplastics in the penis — what does it mean for fertility? We love to hear from you, so please get in touch by email if you have any feedback, comments, or questions about this week's Sunday Supplement. Stay informed and stay healthy! Tim Snaith Newsletter Editor, Medical News Today

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